IPH 266 - Human Genetics as the Basis of Disease

3 credit hours - 45 hours of lecture; one term.
Understand the concepts of molecular genetics and inheritance as the foundation of human genetics and disease states. Prepare for later recognition, application, and workup of dysmorphology in the context of human motor and cognitive development. Learn effective methods to discover a patient’s genetic predisposition and increased risk for disease development.

 

Prerequisite(s): BIO 223 , BIO 233 , BIO 234 , MDA 100 , PSY 111  

Course Outcomes:

1. Explain the structural components and the function of genes.
2. Evaluate the utility of molecular testing methods to diagnose inherited diseases.
3. Differentiate Mendelian disorders based on clinical manifestations.
4. Distinguish inherited diseases based on the molecular mechanisms.
5. Compare different treatment approaches to inherited diseases.
6. Recognize unique human populations that harbor alleles for inherited disorders.
7. Compile clinical, molecular, diagnostic, and treatment information on inherited diseases.
8. Describe the organization of the human genome and explain the molecular mechanisms that contribute to genetic variation and gene mutations.
9. Explain the chromosomal and molecular basis for simple and complex genetic diseases.
10. Use family pedigrees and linkage analysis to predict the genetic basis for a disease and the risk of inheritance.
11. Compare how DNA sequence and epigenetic changes can alter normal gene function.
12. Predict how mutations in oncogenes and tumor suppressors contribute to cancer risk.
13. Describe the ethical issues regarding genomics data and predicting disease risk.