IPH 267 - Foundations of Pharmacology and Pathophysiology

3 credit hours - 45 hours of lecture; one term.
Learn principles of multisystem function and dysfunction at the cellular and molecular levels, specifically as they relate to homeostatic function. Explore the physiologic changes that occur as a result of disease processes, the clinical manifestations indicative of altered health states, and the basis of drug therapies used to treat or affect these conditions. Focus on anatomy, chemistry, microbiology, and physiology with introductory pharmacology, while focusing on their specific applications to clinical practice.

Prerequisite(s): BIO 223 , BIO 233 , BIO 234 ; CHE 112 or CHE 113

Course Outcomes:

Understand pharmacology through pharmacodynamics, pharmacokinetics, and pharmacotherapeutics.
Discuss rationale behind dosing regimens based on pharmacodynamic and pharmacokinetic principles.
Describe the advantages and disadvantages of each route of administration of drugs.
Identify the different types of receptors.
Relate basic receptor theory to drug action.
Identify common second messenger systems.
Define ED50, LD50, therapeutic index, potency, efficacy, EC50, and TD50 as related to dose response.
Define the properties of drugs that govern absorption, distribution and excretion of drugs.
Identify disease states that affect drug absorption and elimination.
Locate and describe the major sites and mechanisms of drug elimination.
Define pharmacokinetic parameters half-life and clearance.
List major pathways of drug metabolism and recognize the various factors that alter metabolizing pathways: age, genetics and disease states.